Author's response to reviews Title: Estrogen Receptor-Beta Gene Polymorphism in women with Breast Cancer at the Imam Khomeini Hospital Complex, Iran Authors:

..found only on exon 7 The SNP was found... ..of allle 1.. ...polymorphisms in exon.. Introduction ..30% (9) , suggesting.. ..incidence (10-16) . ER-α has been studied extensively, but supporting evidence for involvement of ER-β needs further work (26-33). ... Methods: median age 47.49 ± 11.43 years. Is it median age or mean ± SD? Race is repeated twice ..breast cancer tissue.. A ..v. 0.4.0) soft ware (Table 1). ...(16capillaries) Results: ...C convesion to G (C 1176 G) was.. ..(Table 5). Moreover, the allelic frequency of 392C was... (is it 392G?) Discussion a) ...important players in the mechanism... ...cancer (Table3). SNPs... ...suggest the associate of ER-β polymorphisms (is it association?)... ...of 10.5%) suggesting that GC genotype (is it CG?)... ...again, the frequency of GC genotype (is it CG?)... ...than those without LN metastasis in comparison... ...indicating that GC genotype (CG?)... ...population (Table4)... ..disease (Table5). In terms.. ...This indicates that codon 329 polymorphism.. (392?) b) Clarify these two sentences that seem to be contradictory. ....Taken together, codon 392 SNP might influence development of familial breast cancer and LN metastasis but it cannot be considered as a breast cancer risk factor. ...We have identified codon 392 CTC/CTG polymorphism to be associated with an increased risk of breast cancer. Moreover, CG heterozygosity increases in familial breast cancer and LN metastasis... Author contributions have not been stated. References Ref 28:.. Endocrinol Metab. 1998, 83, 4524-4527. Some references have no space and others have a space between volume and pages. ...2005, 94(2): 145-152 or ...2004, 5:31-55. Ref 31-33 and 40 are in a different format KupierKupier? In ref 40.